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Mitochondria As Balancers of Reduction/Oxidation for Intracellular Environment Publisher



Rezaei M1 ; Handali S2 ; Pourahmad J3
Authors

Source: Mitochondrial Metabolism: An Approach to Disease Management Published:2021


Abstract

Reduction/oxidation-dependent reactions affect many cellular functional pathways. Mitochondria are at the center of these processes, as mitochondria both generate reactive oxygen species (ROS) that drive redox-sensitive events and respond to ROS-mediated changes in the cellular redox state. In this chapter, we discuss the regulation of cellular ROS, their modes of production and removal, and the redox-sensitive targets that are modified by their flux. In particular, we focus on the actions of redox-sensitive targets that change mitochondrial functions. We also consider the role of mitochondria in modulating these events, and discuss how redox-dependent events may contribute to the pathology of diseases by influencing mitochondrial function, particularly the involvement of mitochondrial ROS in diabetes, cancer, and neurodegenerative diseases. © 2021 Elsevier Inc. All rights reserved.
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