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Increased Mitochondrial Dna Copy Number and Oxidative Damage in Patients With Hashimoto’S Thyroiditis



Esfahanian F1 ; Hazaveh MM2 ; Garehbagh LH1 ; Falahati K3 ; Ataei M3 ; Sanati MH3 ; Jadali Z4
Authors

Source: Iranian Journal of Public Health Published:2021

Abstract

Background: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy controls (HC). Methods: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto’s thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018. Results: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group. Conclusion: These data suggest the possible involvement of mitochondria and oxidative stress in the patho-physiology of HT. © 2021 Esfahanian et al. Published by Tehran University of Medical Sciences.
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