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Synthesis and Cytotoxicity of Novel Chromenone Derivatives Bearing 4-Nitrophenoxy Phenyl Acryloyl Moiety Publisher



Mahdavi M1, 2 ; Mohammadiizad S1 ; Saeedi M3, 4 ; Safavi M5 ; Ebrahimi SES1 ; Foroumadi A2 ; Shafiee A2
Authors

Source: Journal of the Iranian Chemical Society Published:2016


Abstract

This work describes synthesis of novel chromenone derivatives bearing 4-nitrophenoxy phenyl acryloyl moiety through the reaction of 4-(4-nitrophenoxy)benzaldehydes and 3-acetyl-2H-chromen-2-ones in refluxing toluene. Cytotoxicity of all compounds was evaluated using a tetrazolium (MTT) colorimetric assay against human breast cancer cell line, MDA-MB-231. © 2016, Iranian Chemical Society.
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