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The Role of Interleukin-27 in Atherosclerosis: A Contemporary Review Publisher Pubmed



Jafarizade M1 ; Kahe F2 ; Sharfaei S3 ; Momenzadeh K4 ; Pitliya A5 ; Zahedi Tajrishi F6 ; Singh P7 ; Chi G2
Authors

Source: Cardiology (Switzerland) Published:2021


Abstract

Atherosclerosis is a chronic inflammation characterized by an imbalance between inhibitors and stimulators of the inflammatory system that leads to the formation of atherosclerotic plaques in the vessel walls. Interleukin (IL)-27 is one of the recently discovered cytokines that have an immunomodulatory role in autoimmune and inflammatory diseases. However, the definite role of IL-27 in the pathogenesis of atherosclerosis remains unclear. Recent studies on cardiomyocytes and vascular endothelium have demonstrated mechanisms through which IL-27 could potentially modulate atherosclerosis. Upregulation of the IL-27 receptor was also observed in the atherosclerotic plaques. In addition, circulatory IL-27 levels were increased in patients with acute coronary syndrome and myocardial infarction. A regenerative, neovascularization, and cardioprotective role of IL-27 has also been implicated. Future studies are warranted to elucidate the biologic function and clinical significance of IL-27 in atherosclerosis. © 2021
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