Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type Ii Diabetes Mellitus Publisher



Larijani B¹ ; Heshmat R² ; Ebrahimirad M³ ; Khatami S³ ; Valadbeigi S³ ; Saghiri R³
Source: Enzyme Research Published:2016

Abstract

Background and Aims. In the present study, we have investigated the activity of adenosine deaminase (ADA) as a diagnostic marker in type 2 (or II) diabetes mellitus (T2DM). Design and Methods. The deaminase activity of ADA1 and ADA2 was determined in serum from 33 patients with type 2 (or II) diabetes mellitus and 35 healthy controls. We also determined the proportion of glycated hemoglobin (HbA1c). Results. Our results showed significant differences between total serum ADA (tADA) and ADA2 activities in the diabetic groups with HbA1c < 8 (%) and HbA1c ≥ 8 (%) with respect to the values in healthy individuals (p<0.001). ADA2 activity in patients with high HbA1c was found to be much higher than that in patients with low HbA1c (p=0.0001). In addition, total ADA activity showed a significant correlation with HbA1c (r=0.6, p<0.0001). Conclusions. Total serum ADA activity, specially that due to ADA2, could be useful test for the diagnosis of type 2 (or II) diabetes mellitus. © 2016 Bagher Larijani et al.