Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Evolution of Phage Display Technology: From Discovery to Application Publisher Pubmed



Rahbarnia L1, 2 ; Farajnia S1 ; Babaei H1 ; Majidi J3 ; Veisi K4 ; Ahmadzadeh V1 ; Akbari B5
Authors

Source: Journal of Drug Targeting Published:2017


Abstract

Phage display technology as a selection-based system is an attractive method for evolution of new biological drugs. Unique ability of phage libraries for displaying proteins on bacteriophage surfaces enable them to make a major contribution in diverse fields of researches related to the diagnosis and therapy of diseases. One of the great challenges facing researchers is the modification of phage display technology and the development of new applications. This article reviews the molecular basis of phage display library, and summarizes the novel and specific applications of this technique in the field of biological drugs development including therapeutic antibodies, peptides, vaccines, and catalytic antibodies. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Advances in Phage Display Technology for Drug Discovery, Expert Opinion on Drug Discovery (2015)
2. An Overview on Display Systems (Phage, Bacterial, and Yeast Display) for Production of Anticancer Antibodies; Advantages and Disadvantages, International Journal of Biological Macromolecules (2022)
3. Development of a Novel Human Scfv Against Egfr L2 Domain by Phage Display Technology, Current Pharmaceutical Design (2017)
Experts (# of related papers)
View all Related Experts
Ehsan Khalili (2)
Mahdi Aminian (2)
Other Related Docs
4. Predicting the Future: Phage Therapy, Egyptian Journal of Veterinary Science(Egypt) (2022)
5. Bacteriophages and Phage-Inspired Nanocarriers for Targeted Delivery of Therapeutic Cargos, Advanced Drug Delivery Reviews (2016)
6. Construction of Genetically Engineered M13k07 Helper Phage for Simultaneous Phage Display of Gold Binding Peptide 1 and Nuclear Matrix Protein 22 Scfv Antibody, Colloids and Surfaces B: Biointerfaces (2017)
7. Human Gut Bacteriophageome: Insights Into Drug Resistance Mechanisms in Tuberculosis, Interdisciplinary Perspectives on Infectious Diseases (2025)
8. Current Trends in Targeted Therapy for Drug-Resistant Infections, Applied Microbiology and Biotechnology (2019)
9. Neutralizing Anti-Diphtheria Toxin Scfv Produced by Phage Display, Biotechnology Letters (2024)
10. Evaluating the Effectiveness and Safety of a Novel Phage Cocktail As a Biocontrol of Salmonella in Biofilm, Food Products, and Broiler Chicken, Frontiers in Microbiology (2024)
11. Targeting Breast Cancer: The Promise of Phage-Based Nanomedicines, Breast Cancer Research and Treatment (2025)
12. The Role of Nanotechnology in Overcoming Barriers to Phage Therapy: An Overview, Future Virology (2023)
13. A Review of the Fighting Acinetobacter Baumannii on Three Fronts: Antibiotics, Phages, and Nanoparticles, Molecular Biology Reports (2024)
14. Cell Targeting Peptides As Smart Ligands for Targeting of Therapeutic or Diagnostic Agents: A Systematic Review, Colloids and Surfaces B: Biointerfaces (2017)
15. Development and Clinical Application of Bispecific Antibody in the Treatment of Colorectal Cancer, Expert Review of Clinical Immunology (2020)
16. Isolation of a Novel Anti-Kdr3 Single-Chain Variable Fragment Antibody From a Phage Display Library, Iranian Journal of Allergy# Asthma and Immunology (2019)
17. Production of Recombinant Human Scfv Against Tetanus Toxin Heavy Chain by Phage Display Technology, Monoclonal Antibodies in Immunodiagnosis and Immunotherapy (2015)
18. Development and Characterization of Phage Display-Derived Anti-Toxin Antibodies Neutralizing Tcda and Tcdb of Clostridioides Difficile, Microbiology Spectrum (2023)
19. A Minireview on the in Vitro and in Vivo Experiments With Anti-Escherichia Coli O157:H7 Phages As Potential Biocontrol and Phage Therapy Agents, International Journal of Food Microbiology (2017)
20. Specification of Bacteriophage Isolated Against Clinical Methicillin-Resistant Staphylococcus Aureus, Osong Public Health and Research Perspectives (2019)